Coherence EEG Journal Club meeting

At Fossvogur, 24.01.2019 Kl 16:00

Road map for TMS and schizophrenia project in Iceland

Reykjavík University, Iceland

by Ovidiu C. Banea

On June 2018 a project dedicated to schizophrenia patients with auditory verbal hallucinations and their treatment with trans-cranial magnetic stimulation started in Iceland. 

The perfect coordination between researchers from Kleppur Psychiatric Hospital, Biomedical and Neural Engineering Institute at Reykjavík University, School of Business - Department of Psychology, National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, United States and Clinical Neurophysiology Unit from National University Hospital - Landspítali Iceland made possible the recruitment and treatment of 12 patients with consequent analyses with multi-metric approach.

Measurements of the brain activity was performed before and after the treatment with P50, N100-P300 complex, resting state and auditory motor-task with 256 High Density-EEG recordings, cortical silent period and psychometric scales.

The team could organize and present their methodology, results and preliminary data in 14 original works during several local and international meetings in France, Japan, Poland, Portugal and Austria (see all works here).

On 13th of December we met at Reykjavik University and we discussed the detailed of the most important aspects of the AVH-TMS Icelandic Clinical trial - publishing the results in a peer review international journals. Two teams were formed, one at Reykjavik University and one at University National Hospital. The first team will process event related potential results at BNE and the second team will put together all data obtained at Fossvogur Landspítali and at Kleppur Psychiatric Hospital. By the end of January 2020 the process structure and software analyses will start.

Assessment of the lower limb weakness and suspected amyotrophic lateral sclerosis

A patient with suspected motor neuron disease (MND or ALS) was assessed with TMS in our Unit in Iceland here. There were no signs of EMG criteria. We further investigated with TMS and it seems that there is a lower spinal level delay of the central motor conduction.

FIRST HEILA VISTFRÆÐI JOURNAL CLUB MEETING

Possible evidence of human ability to detect Earth's magnetic field found HERE.

First Journal Club Meeting at Reykjavik, Iceland

We talk about the 6th human sense, MAGNETO-RECEPTION IN HUMANS

D wave IONM in Iceland. Third case: Meningocele

IONM for medular herniation at T5 level Use of D-wave 

HERE

Ovidiu C. Banea, Halldór Skúlasson, Ingvar H. Ólafsson, Aron D. Jónasson and Eysteinn Ívarsson

52 y.o. with meningocele.

Modalities:

MEP with direct cortical stimulation (560 V to the left and 890 V to the right) with train of five from C1-C2 and C3-C4 to:
- Right EDC, APB, TA, AH
- Left APB, TA, AH
SSEP were performed from lower tibialis nerve and recorded to FpZ-Cz´ and from median nerves to Fpz-C3´ and Fpz-C4´. Both were controlled at popliteal fossa level (TN) and spinal C7 (TN and MN).
D wave was obtained rotral and caudal to the defect with D-wave electrodes after stimulation at 1Hz continuously (199V)
TOF was used from rioght median nerve to right APB.  was 100-99% during the entire surgery.
EEG was analized from C4´-Fpz and Fpz-C3´channels.

Results:
At the beginning of the surgery MEP was obtained in the upper limbs and left lower limb muscles. Right AH muscle was very difficult to elicit with 890 V, while TA in the right side was not obtained. At the end of the surgery the MEP were similar with those obtained at the beginning.

SSEP showed normal latencies during all the procedure. At the middle of the surgery, SSEP from right TN decreased 10-20% in amplitude. Rapidly we confirmed the decreased TA when asked the anaesthesiologist. After 5 minutes the SSEP recovered baseline values.

D-Wave was unchanged during all the spine manipulations and the defect corrective procedures.

Conclusion:
The IONM was successful and all modalities showed normal evolution. We do not expect sensory or motor new neurological deficits.

Technical data:
-Surgery duration 4,5 hours.
-Material: 11 subdermal needle paired electrodes, 4 monopolar subdermal needle electrodes, 2 D-wave electrodes, 8 Cork-screw electrodes, 1 ground electrode.

Neurophysiology Plus Iceland © 2019

Meningocele at T5 level.

 After surgery.

 SSEP upper and lower limbs

 MEP in lower limbs

 D wave: left rostral and right caudal

D wave: upper trace rostral, lower trace caudal. Latency 5-6 ms and amplitude 8uV.

The reference electrode was placed between two electrodes. (phase reversed peak).

It would be useful to reference both electrodes to a proximal sub-dermal well inserted electrode.

VAFO project Iceland, QEEG, P50, P300 recordings

On 11th of August 2018 VAFO project started officially with the first healthy subject data acquirement in the Icelandic Center for Neurophysiology, Department of Biomedical Engineering, Reykjavik University.

Valerio Gargiulo, Fabio Barollo, Eysteinn Ívarsson and Martin Freiler

Dr Sigurjón Stefánsson gave us important insights on methodology of P50 and P300. 

Continuous averaging is still a desired EEG system option to avoid artifacts during recordings.

VAFO project Iceland: P50, P300, QEEG objective measurements for schizophrenia patients

by Neurophysiology Plus Iceland

Reykjavik, 9th of August 2018

A team of young researchers leaded by biomedical engineer Dr Paolo Gargiulo, from Reykjavík University, Department of Biomedical Engineering performed successfully the first data acquiring for a healthy subject recording P300, P50 and dense array 256-channel EEG.

P300 was first used in Iceland by Sigurjón B. Stefánsson and Anna L. Möller since the nineties.
Scientific data was published in 1995 and 2001 and 2005.
In July 2017 P300 returned to Iceland in Clinical Neurophysiology Unit of Landspitali (here).
P50 was acquired first time in patient with tinnitus on 20th of February 2018 in a paired-stimulus
or conditioning-testing paradigm, (S1, conditioning click; S2, testing click; 500 ms inter-click interval; 10,000 ms inter-pair interval). This was a trial of 30 paired stimulus with sensory gating with stimulus in the left and observed from Cz-A2 (right cortex) and with absent wave and response from the left Cz-A1 channel when stimulus was applied for the right ear.

Today the team formed by:

Viktor Díar Jónasson, Clinical Psychology master student at the Department of Psychology, Reykjavik University
Fabio Barrolo, PhD student at Reykjavik University Iceland / Aston University, Birmingham, UK, Biomedical Engineering
Valerio Gargiulo, Research assistant at the Icelandic Center for Neurophysiology, legal advisor and EEG technologist at Department of Biomedical Engineering, Reykjavík University
Eysteinn Ívarsson, Psychologist and technologist at Clinical Neurophysiology Unit, National University Hospital of Iceland
Ovidiu Banea, PhD student at Reykjavík University, Department of Biomedical Engineering and Clinical Neurophysiologist MD at National University Hospital of Iceland

performed both P300 and P50 acquisition with dense array 256 channel EEG system at the Icelandic Center for Neurophysiology, Department of Biomedical Engineering, Reykjavík University

Video on YouTube

artifact removal process, 256 channels EEG raw data

256 brain P50 map and selection of the 4 representatives lines

Valerio Gargiulo, Viktor Díar Jónasson, Eysteinn Ívarsson

Fabio Barollo

P 50 experimental

P300 experimental

256 channel dense array EEG, set-up